Job Description
Tenaya Therapeutics is a clinical-stage biotechnology company committed to a bold mission: to discover, develop and deliver potentially curative therapies that address the underlying drivers of heart disease. Tenaya's most advanced candidates include TN-201, a gene therapy for MYBPC3-associated hypertrophic cardiomyopathy (HCM), TN-401, a gene therapy for PKP2-associated arrhythmogenic right ventricular cardiomyopathy (ARVC), and TN-301, a small molecule HDAC6 inhibitor being initially developed for heart failure with preserved ejection fraction (HFpEF). Tenaya also has multiple early-stage programs progressing through preclinical development.
Tenaya is headquartered in South San Francisco, California, USA, with a team that comprises over 70 employees. Inspired by the majesty of Tenaya Peak in Yosemite National Park, our name represents the tenacity of our team in reaching our ultimate peak – the delivery of new therapies for heart disease to the patients who need them.
For more information, please visit and follow us on LinkedIn.
Diversity & Inclusion is a core Value for Tenaya Therapeutics, and we encourage those from under-represented communities to apply. Tenaya Therapeutics has an immediate need for an experienced manager or associate scientist, depending on experience, in biomarker sample operations management and biomarker assay development for heart failure gene therapy. This will be a key role responsible for both nonclinical and clinical biomarker sample and data management covering the lifecycle of the samples. The candidate will work across functions to initiate and deliver high-quality biomarker sample results to inform key decisions for drug development. Expertise in biomarker assay development and sample management at all stages of development will be essential.
Responsibilities - Manage sample logistics and operations for biomarker sample analysis, collaborating with study management team, central laboratory, specialty lab vendors and data management team
- Contribute to nonclinical and clinical trial documents including sample collection sections of study protocols, central laboratory specifications and laboratory manuals, data transfer agreements and study reports
- Work with program management and clinical teams to create and manage timelines for biomarker data and report delivery for both nonclinical and clinical study sample analysis
- Support contracting for assay development and sample analysis, including development of statements of work and master services agreements with bioanalytical labs
- Develop and validate key biomarker assays internally and at CROs for use on nonclinical and clinical trial biomarker samples, including scientific input on assay method development, and document review of plans and reports
- Design, execute and interpret experiments to support and broaden the biological understanding of validated biomarker assays, and how the results reflect heart disease progression and response to gene therapy
- Data analysis to validate and deepen insights from CRO-generated results of heart disease and immunogenicity biomarkers
Requirements - A 4-yr degree in a relevant science with > 10 years relevant industry experience or MS with 6+ years' industry experience
- Experience with clinical trial biomarker sample logistics and operation required, including sample database and inventory management
- Experience with assay development and validation in multiple platforms, e.g., qPCR and ddPCR, LC-MS/MS, ligand binding assays, immunohistochemistry, microscopy, flow cytometry
- A background in cardiac biology and disease, genetic diseases, and/or cell or gene therapies preferred
- Experience with management of CROs required
- Knowledge and understanding of nonclinical and clinical trials and the role of biomarkers and translational medicine within those studies
- The ability to manage multiple tasks efficiently, to communicate clearly and effectively, as well as to build open and collaborative relationships are essential.
- Ability to function well both independently and as part of a small, dedicated team
- A positive attitude and strong attention to detail are required.
Tenaya takes into account a wide range of factors when determining compensation including not limited to skill sets, experience, interview performance and organizational need.
We will make an offer based on geo-located salary bands based on data collected from Aon/Radford. As of 1/1/2023, for individuals assigned and/or hired to work in the San Francisco Bay Area in the state of California, your base salary will fall within the band(s) below. This base salary range is an estimate, and the actual base salary may vary based on Tenaya's compensation practice. Please also keep in mind that the benefits, bonus, and the equity portion of your offer is not included in these numbers and represents a significant portion of your total rewards package at Tenaya. Should you reach the verbal offer stage of Tenaya's hiring process, we will review the base salary, benefits, bonus target and equity grant value with you at that time. {{JOB}} range is {{SALARY_RANGE}}
Benefits We offer a dynamic start-up environment and a collaborative, passionate team that is focused on a compelling vision and mission.
We offer competitive salary and stock options. Excellent medical and non-medical benefits. Paid vacation, sick time and holidays.
State-of-the-art, built-to-suit office and lab space, part of a larger cluster of biotech companies, with amenities that include a bowling alley and onsite gym.
Shuttle service to/from Caltrain, BART and the South San Francisco Ferry.
Tenaya is proud to be an equal opportunity workplace.
Job Tags
Work at office, Immediate start,